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The clinical application of preimplantation genetic diagnosis
(PGD) has provided an alternative approach for the prevention
of affected pregnancies in couples at high reproductive risk.
The frequent contribution of genetic factors to infertility problems
makes PGD of particular value for assisted reproductive practices.
In addition, the selection of euploid embryos for transfer has
a strong impact on IVF efficiency as aneuploidics are the main
cause of spontaneous abortions and implantation failures. In this
study, the clinical outcome in PGD cycles is presented. The list
of monogenic disorders for which PGD is performed is rapidly extending
and the safety of the procedure has lead to an increasing interest
among couples at high reproductive risk. Following PGD for aneuploidy,
a higher implantation rate and a lower incidence of spontaneous
abortions are obtained in patient categories where aneuploidy
is a prominent cause of reproductive failure. In view of these
findings, PGD has become an integral part of assisted reproductive
techniques for the prevention of affected pregnancies and improvement
of IVF efficiency.
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