Kava-Kava administration reduces anxiety in perimenopausal women Cagnacci A, Arangino S, Renzi A, Zanni AL, Malmusi S, Volpe A. Maturitas 2003 Feb 25;44(2):103-9 |
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Disturbances
of mood, such as anxiety and depression, increase in the perimenopausal
period. Hormone replacement therapy or neuroactive drugs represent
useful treatments for these disturbances but may be contraindicated
or not accepted. Herein it was investigated the efficacy of Kava-Kava,
an extract of Piper Methysticum, on mood of perimenopausal women.
DESIGN: A 3-months randomized prospective open study investigating
in perimenopausal women modifications induced by calcium supplementation
(control; n=34), calcium plus Kava-Kava at the dose of 100 mg/day
(n=15) or calcium plus Kava-Kava at the dose 200 mg/day (n=19).
Anxiety was evaluated by the State Trait Anxiety Inventory (STAI);
depression by the Zung's scale (SDS), and climacteric symptoms
by the Greene's scale. Evaluations were performed at baseline
and after 1 and 3 months. |